Postconditioning and Controlled Reperfusion
نویسندگان
چکیده
منابع مشابه
Myocardial postconditioning: reperfusion injury revisited
CORONARY HEART DISEASE is the leading cause of death in the Western world and represents one of the major burdens on healthcare systems today. Targeting those strategies that limit the damage sustained as a result of a lethal ischemic insult has been a major goal for many years. One of these strategies, termed ischemic preconditioning, in which brief nonlethal episodes of ischemia protect the m...
متن کاملMyocardial postconditioning: reperfusion injury revisited
CORONARY HEART DISEASE is the leading cause of death in the Western world and represents one of the major burdens on healthcare systems today. Targeting those strategies that limit the damage sustained as a result of a lethal ischemic insult has been a major goal for many years. One of these strategies, termed ischemic preconditioning, in which brief nonlethal episodes of ischemia protect the m...
متن کاملMyocardial postconditioning: reperfusion injury revisited
CORONARY HEART DISEASE is the leading cause of death in the Western world and represents one of the major burdens on healthcare systems today. Targeting those strategies that limit the damage sustained as a result of a lethal ischemic insult has been a major goal for many years. One of these strategies, termed ischemic preconditioning, in which brief nonlethal episodes of ischemia protect the m...
متن کاملPI 3-kinase regulates the mitochondrial transition pore in controlled reperfusion and postconditioning.
OBJECTIVE We investigated whether phosphatidylinositol 3-kinase (PI3K) might regulate mitochondrial permeability transition pore (mPTP) opening in hearts reperfused with either low pressure or postconditioning. METHODS Male Wistar rat hearts (n=72) were perfused according to the Langendorff technique, exposed to 30 min of ischemia, and assigned to one of the following groups: (1) reperfusion ...
متن کاملPostconditioning: reduction of reperfusion-induced injury.
Reperfusion has the potential to introduce additional injury that is not evident at the end of ischaemia per se, i.e. reperfusion injury. Reperfusion injury is expressed as endothelial and microvascular dysfunction, impaired blood flow, metabolic dysfunction, cellular necrosis, and apoptosis. There is an impressive array of mechanisms contributing to reperfusion injury. Postconditioning, define...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2009
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e3181bf1dac